Giulio Sancini

CURRICULUM VITAE

Assistant Professor of Human Physiology, Specialist in Applied Pharmacology, Dr. Sancini has focused his research activity mainly on neurosciences, nanomedicine and nanotoxicology.  Dr.  Sancini, has a long experience in electrophysiological measures of synaptic currents. He has an established know how and equipment in neurophysiology, cellular electrophysiology, pharmacology and in vivo models to study the (1) impact of anthropogenic nanoparticles on the respiratory system and to evaluate their potential for translocation to the systemic level, (2) the biodistribution and biocompatibility of engineered nanoparticles (targeted delivery). Dr. Sancini research has been funded by european FP7 (NAD project, Nanoparticles for Diagnosis and therapy of Alzheimer’s Disease), FP6  (BONSAI project, Bio-Imaging with Smart Functional Nanoparticles) and – Italian Ministry Research Program – MIUR- PRIN 2012, prot. 20128xwktx “A molecular and functional study of adam10 at the Huntington’s disease synapse”. Dr. Sancini has published more than 48 papers in reputed journals and  he has been serving as an editorial board member of repute. Dr. Sancini is head of the Physiology Unit at the School of Medicine and Surgery of the University of Milano-Bicocca. Dr. Sancini is member of the spin off “Amypopharma for the technological industrial transfer of the  International Patent: “Liposomes active in-vivo on degenerative diseases”: ca2877765a1, ep2866790a1, us8877236, us20140004172, wo2014000857a1

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 MAIN RESEARCH ACTIVITIES

  • Interaction of engineered nanoparticles and air pollutants within the central nervous system
  • Assessment of the permeability and biodistribution of engineered nanoparticles for targeting the central nervous system in in vitro BBB models and in vivo
  • Transmembrane voltage-gated currents and postsynaptic potentials in cultured neurons and in cerebral slices incubated in vitro.
  • Assessment of pulmonary and systemic response to particulate air pollution (PM) exposure in in vivo models: study of the mechanisms related to the translocation of PM through the alveolar-capillary barrier, identification of new markers of risk.
  • Assessment of functional alterations of the blood-brain barrier (BBB) related to Alzheimer’s disease and related to the ischemic and hypoxic  events
  • Respiratory bio-mechanics related to fluid dynamic alterations that occur during pulmonary interstitial edema

Sancini is Tutor of Dr. Greta Forcaia currently engaged in the XXXII Neuroscience PhD Program “Neurophysiological studies to evaluate clinical potential of brain targeted nanoparticles”

AIMS:  Ex vivo and in vivo neurophysiological studies will be perform to evaluate nanoparticle (NPs) action and their interaction with central nervous system (CNS) elements, their possible effects on neuronal response (both evoked and spontaneous) and synaptic transmission studying neurons and their networks interaction in particular in cortex and hippocampus.

MOST RELEVANT PUBLICATIONS

  1. Dal Magro R, Ornaghi F, Cambianica I, Beretta S, Re F, Musicanti C, Rigolio R, Donzelli E, Canta A, Ballarini E, Cavaletti G, Gasco P, Sancini G. ApoE-modified  solid lipid nanoparticles: A feasible strategy to cross the blood-brain barrier. J Control Release. 2017 Mar 10;249:103-110. doi: 10.1016/j.jconrel.2017.01.039.
  2. Sancini, G, Dal Magro, R , Ornaghi, F, Balducci, C, Forloni, G, Gobbi, M, Salmona, M, Re, F. Pulmonary administration of functionalized nanoparticles significantly reduces beta-amyloid in the brain of an Alzheimer’s disease murine model. Nano Research, Volume 9, Issue 7, 1 July 2016, Pages 2190-2201. doi: 10.1007/s12274-016-1108-8
  3. Mancini S, Minniti S, Gregori M, Sancini G, Cagnotto A, Couraud PO, Ordóñez-Gutiérrez L, Wandosell F, Salmona M, Re F. The hunt for brain Aβ oligomers by peripherally circulating multi-functional nanoparticles: Potential therapeutic approach for Alzheimer disease. Nanomedicine. 2016 Jan;12(1):43-52.doi: 10.1016/j.nano.2015.09.003.
  4. Balducci C, Mancini S, Minniti S, La Vitola P, Zotti M, Sancini G, Mauri M, Cagnotto A, Colombo L, Fiordaliso F, Grigoli E, Salmona M, Snellman A, Haaparanta-Solin M, Forloni G, Masserini M, Re F. Multifunctional liposomes reduce brain β-amyloid burden and ameliorate memory impairment in Alzheimer’s disease mouse models. J Neurosci. 2014 Oct 15;34(42):14022-31. doi:10.1523/JNEUROSCI.0284-14.2014.
  5. Sancini, G., Farina, F., Battaglia, C., Cifola, I., Mangano, E., Mantecca, P., Camatini, M., Palestini, P. Health risk assessment for air pollutants: Alterations in lung and cardiac gene expression in mice exposed to milano winter fine particulate matter (PM2.5) (2014) PLoS ONE, 9 (10), art. no. e109685, DOI: 10.1371/journal.pone.0109685e

To see the full pubs list visit Scopus.

Elisabetta Donzelli
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