Enrico Capuzzi

Enrico Capuzzi joined the University of Brescia where he graduated from Medical School in Medicine and Surgery in 2005 and subsequently as Medical Specialist in Psychiatry in 2011. Between 2014-2015 he obtained the Master’s Degree of second Level in ” Epidemiological Biostatistics and Methodology ” at the University of Pavia. From 2015 he’s PhD student in Neuroscience at the University of Milan Bicocca, XXXI cycle. He is a researcher at ASST in Monza, chair of Psychiatry (Prof. Massimo Clerici) where his main interest involves the role of biological markers related to psychiatric illness, as well as the study of mental pathology in the prison setting.

RESEARCH PROJECT

Recent suicide attempts and serum lipid profile in subjects with mental disorders: a cross-sectional study

  • Track: Clinical Neuroscience
  • Tutor: Massimo Clerici

There is growing evidence supporting the role of immune alterations in the pathogenesis of schizophrenia, including several studies on proinflammatory citokines levels. A recent meta-analysis of cytochine alterations in Schizophrenia found an abnormal elevation in cytokines levels in first episode schizophrenia patients (FEP) and relapsed schizophrenia inpatients, as a state markers (normalized levels after antipsycothic treatments: IL-1β, IL-6) or trait markers (elevated levels also following antipsycothic treatments: TNF-α). However antipsychotics seem to have an anti-inflammatory effect, as reported in a meta-analysis of antipsycothic-induced cytokine changes in schizophrenia, although with different mechanisms. Aberrant citokine levels were also observed in first degree relatives of schizophrenia patients, suggesting that immune system abnormalities may be an endophenotype of the disorder.
Schizophrenia is related to several neurocognitive impairments, already detectable not only in FEP patients but also in ultra high risk psychosis patients and in unaffected first-degree relatives (endophenotype), including social cognition, defined as “the capacity to attribute thoughts, desires, intentions and beliefs to others”. Although there are several studies of association between cytokines as inflammatory marker and the clinical expression of schizophrenia in FEP patients, there is no study involving social cognition; one study, however, has reported a reduction in a social cognition task in acute inflammation state (after endotoxin injection) among 115 healthy participants. The effects of the antipsycothic treatments on social cognition seem small, driven by atypical rather than typical antipsycothics. Because schizophrenia is linked to immunological factors, it looks interesting to explore the alteration in cytokine levels in FEP patients, that may contribute to impairment in social cognition, with antipsycothic therapy as possible anti-inflammatory agent.

RECENT PUBLICATIONS AND CONGRESSES

Publications

Congresses

  • Toccagni A., Capuzzi E., Deste G., Galluzzo A., Sacchetti E.:“Fractional anisotropy  of the corpus callosum and neurocognitive correlates in drug-naïve schizophrenic patients.” Third meeting of psychotherapy, psychopharmacotherapy, integrated treatments “Rome, 18th-20th November 2010
  • Piccinini G.,  Giambra A., Cacciani P., De Peri L., Barlati S.D., Poli R., Deste G., Togni C., Capuzzi E., Buila G., Bettinsoli F., Zorzan N., Vita A., Sacchetti E.: “Computerized cognitive training in schizophrenia: the cogpack. ” Third meeting of psychotherapy, psychopharmacotherapy, integrated treatments “Rome, 18th-20th ,  November 2010
  • Castellano F., Lax A., Gamba G., Santambrogio J., Tremolada M., Amidani F., Rossetti A., Capuzzi E., Crocamo C., Nava R., Carrà G., Papagno C., Clerici M.: “Facial Emotion recognition and disorganization in subjects with schizophrenia and alcohol, substance use disorder”  19th National Congress of the Italian Society of Psychopathology, Milan;   23rd European Congress of Psychiatry Vienna, 28th-31st  march, 2015
  • E.Capuzzi, E.Pini, I.Riboldi, M.Provenzi, C.Crocamo,G.Carrà, M.Clerici: “Predictors of referral to high security forensic services among mentally ill inmates admitted to  inpatient care prison”  20th National Congress of the Italian Society of Psychopathology, Milan, 23rd-26th february 2016
  • E. Capuzzi, I.Riboldi, F.Bartoli, C.Crocamo, M.Bava, A. Lax , G. Carrà, M. Clerici: “Clinical and Psychopatological correlates of treatment wiyh Long-Acting Injectable Antipsychotics in patients with Psychosis: an observational comparative study” Young Psychiatrists Section – Italian Society of Psychiatry.  Rome, 5th-6th  may 2016
  • E.Capuzzi, M. Vecchio, I. Riboldi, F. Bartoli, M. Clerici. “The prescription of  psychopharmacological treatment in a sample of prisoners: a cross-sectional study” 21st National Congress of the Italian Society of Psychopathology, Rome 22nd-25th February 2017
  • Bartoli F., Riboldi I., Bava M., Capuzzi E, Di Brita C, Trotta G, Verrengia E, Clerici M. “Predictors of inpatient treatment with long-acting injectable antipsychotics: a pilot study”.  Young Psychiatrists Section – Italian Society of Psychiatry. Cagliari, 21st-23rd  september 2017

FURTHER INFO

To get further details and the full pub list, go to ResearchGate

 

 

Elisabetta Donzelli
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