Curriculum Vitae
I am Jacopo Mariani and I was born in Sesto San Giovanni on 31 March 1994. In October 2019, I obtained the master’s degree in medical biotechnology from the University of Milano-Bicocca. My Thesis’ title was: “VCOOL (Ventricular Cooling Device): sviluppo di un dispositivo medico per il trattamento dell’ictus ischemico acuto attraverso l’induzione di ipotermia cerebrale selettiva”. During my thesis’ period I took part in different rat’s ischaemic stroke experiments. I cooperate with a French research group (CERMEP) in Lyon, where I approached to MRI techniques. The MRI images acquisition helped me to became confident in using specific analysis software (FSLeyes and MIPAV). In November 2019 I continued my University career by winning the Neuroscience PhD programme with the project “Multi-centre Translational Trial of Remote Ischemic Conditioning in Acute Ischemic Stroke (TRICS)”. Currently, I am setting Staining Techniques and Cutting slices protocols, in order to perform histological analysis and carrying out the project.
PhD Research Project
Multi-center Translational Trial of Remote Ischemic Conditioning in Acute Ischemic Stroke (TRICS)
- Track: Experimental Neuroscience
- Tutor: prof Carlo Ferrarese
Treatment for acute ischemic stroke has evolved rapidly after the efficacy of recanalization therapies (intravenous thrombolysis and endovascular thrombectomy) was proved in large clinical trials. Nonetheless, a significant number of patients does not achieve a good outcome despite recanalization therapies or is excluded from recanalization therapies due to contraindications. Remote ischemic conditioning (RIC) is a simple non-pharmacological therapy, which consists in delivering a transient ischemic insult in the limbs to achieve a neuroprotective effect against cerebral ischemia. RIC has been reported as a remarkable neuroprotective strategy, which has already been investigated by basic research experiments in term of pathophysiological mechanisms and pre-clinical trials by individual scientists. For these reasons, RIC displays a highly promising translational profile.
The aim of this project is to perform a to investigate the efficacy of RIC in an experimental ischemic stroke.
Publications
- Beretta S., A. Versace, Beatrice Martini, M. Viganò, S. Diamanti, C. Pini, G. Paternò, D. Carone, Jacopo Mariani, L. Monza, M. Riva, Giada Padovano, E. Rossi, G. Citerio, G. Castoldi, F. Padelli, Isabella Giachetti, D. Aquino, C. Giussani, E. Sganzerla, C. Ferrarese. “Head down tilt 15° in experimental intracerebral hemorrhage: a randomized noninferiority safety trial” European Journal of Neurology 2020, 0: 1–7; doi:10.1111/ene.14560
- Tettamanti M., Beretta S., Pignataro G., Fumagalli S., Perego C., Sironi L., Pedata F., Amantea D., Bacigaluppi M., Vinciguerra A., Valente A., Diamanti S., Mariani J., Viganò M., Santangelo F., Zoia C., Rogriguez-Menendez V., Castiglioni L., Rzemieniec J., Dettori I., Bulli I., Coppi E., Gullotta G., Bagetta G., Martino G., Ferrarese C., De Simoni M. “Multicentre translational Trial of Remote Ischaemic Conditioning in Acute Ischaemic Stroke (TRICS): protocol of multicentre, parallel group, randomised, preclinical trial in female and male rat and mouse from the Italian Stroke Organization (ISO) Basic Science network” BMJ Open Science 2020;4:e100063. doi:10.1136/bmjos-2020-100063
