CURRICULUM

After having obtained the Master degree in Medical Physics at the University of Trieste (1995) and the PhD in Physics on the development of X-ray phase contrast imaging for biomedical applications (1999), I moved to the European Synchrotron Radiation Facility (Grenoble, France), where I have been managing since 2003 the imaging and radiotherapy laboratory. Recently, I have focussed on the potential use of X-ray microbeams in the modulation of the cerebral function and in the treatment of pharmaco-resistant epilepsy. Since 2013, I have been the chairman of the European Project FP7 COST-SYRA3 (TD1205). http://www.syra3.eu http://www.esrf.fr/UsersAndScience/Experiments/Imaging/ID17

RESEARCH INTEREST

• Development and application of high resolution phase contrast X-ray imaging
• Development of radiation therapy technique using quasi-monochromatic X-rays.
• Development of radiosurgery techniques using submillimetric X-ray beams (microbeam radiation therapy)
• Coordination at the European scale of medical developments in radiation therapy using X-ray microbeams.

RESEARCH PROGRAM

Development and application of microbeams in the modulation of the brain function in animal models.

MOST SIGNIFICATIVE PAPER

1. Synchrotron-generated microbeam sensorimotor cortex transections induce seizure control without disruption of neurological functions. Romanelli P, Fardone E, Battaglia G, Bräuer-Krisch E, Prezado Y, Requardt H, Le Duc G, Nemoz C, Anschel DJ, Spiga J, Bravin A. PLoS ONE 2013; 8(1): e53549. doi:10.1371/journal.pone.0053549
2. Response of the rat spinal cord to X-ray microbeams. Laissue JA, Bartzsch S, Blattmann H, Bräuer-Krisch E, Bravin A, Dalléry D, Djonov V, Hanson AL, Hopewell JW, Kaser-Hotz B, Keyriläinen J, Laissue PP, Miura M, Serduc R, Siegbahn AE, Slatkin DN. Radiotherapy and Oncology 2013; Jan;106(1):106-11
3. Synchrotron-generated microbeam radiosurgery: a novel experimental approach to modulate brain function. Romanelli P, Bravin A. Neurological research 2011; 33 (8) 825-831
4. High-resolution, low-dose phase contrast X-ray tomography for 3D diagnosis of human breast cancers. Zhao Y, Brun E, Coan P, Huang Z, Sztrókay A, Diemoz PC, Liebhardt S, Mittone A, Gasilov S, Miao J, and Bravin A PNAS 2012; November 6, vol. 109, no. 45, 18290–18294
5. X-Ray Phase-Contrast Imaging with Nanoradian Angular Resolution. Diemoz PC, Endrizzi M, Zapata CE, Pešić ZD, Rau C, Bravin A, Robinson IK, and Olivo A Physical Review Letters 2013; 110, 138105

FOREIGN COLLABORATIONS

• University of Munich (Prof. P. Coan)
• University College of London (Dr. A. Olivo)
• University of Bern (Prof. V. Djonov)
• University of Wollongong, Australia (Prof. M. Lerch)
• University of Heidelberg (Prof. U. Oelfke)