Arianna Scuteri

CURRICULUM VITAE

Prof. Arianna Scuteri got her Degree in Medical Biotechnology, Faculty of Medicine University of Milan, Italy, with the dissertation “Study of the molecular mechanisms activated by Paclitaxel in nervous-like cells”, Vote 110/110 cum laude. In 2005, she got her PhD in Neuroscience, Faculty of Medicine University of Milano-Bicocca, Italy, with the dissertation: “Study of the molecular mechanisms involved in oxaliplatin neurotoxicity. 

During years spent at University Milano-Bicocca, she got many post doc fellows and she had the role of Principal investigator and scientific coordinator of the project “Mechanisms of Mesenchymal Stem Cells positive action on the diseases of both central and peripheral nervous system” funded by MIUR (Firb Futuro in ricerca RBFR08VSVI_001). 

She is now Associate Professor (BIO/16 Anatomy), at the School of Medicine and Surgery, University of Milano-Bicocca. 

Since 2019 she is Scientific Board Member of Milan Center for Neuroscience (NeuroMI), Molecular and Cellular Neuroscience Area. Moreover, Prof. Arianna Scuteri is member of the Italian Society of Anatomy and Histology (SIAI) and of Milan Center for Neuroscience (NeuroMI). She is also an editorial board member of many international journals (such as World Journal of Stem Cells BioMed Research Central (Neuroscience area) ISRN (International Scholarly Research Network) Neuroscience), ad hoc reviewer and grant evaluator (2020) for the Israel Science Foundation (ISF). 

Besides research activity, Prof. Arianna Scuteri also carries out teaching activity of Anatomy and Histology for Master Degree course of Medicine, Dentistry and for BSc of Optometry at the University Milano-Bicocca. She is also professor of the PhD Program in Neuroscience, University Milano- Bicocca. 

RESEARCH ACTIVITY 

Main topics of research: 

Set up of experimental in vitro and in vivo models of neurological diseases. Development of in vitro models to evaluate the antiproliferative and/or neurotoxic effects of different molecules and Profugs. Real Time PCR techniques for the study of neurological diseases. In vitro and in vivo evaluation of Mesenchymal Stem Cells positive action on the diseases of both central and peripheral nervous system (i.e. Diabetic neuropathy and Multiple Sclerosis), with a particular focus on direct contact and intercellular interactions. Neuroprotective molecules screening. 

MOST RELEVANT PUBLICATIONS 

  • Donzelli E, Scuteri A. Mesenchymal Stem Cells: A Trump Card for the Treatment of Diabetes? Biomedicines 2020, 8, 112. doi.org/10.3390/biomedicines8050112.
  • Fumagalli G, Monfrini M, Donzelli E, RoProfiguez-Menendez V, BonanProfini B, Figliuzzi M, Remuzzi A, D’Amico G, Cavaletti G, Scuteri A. Protective Effect of Human Mesenchymal Stem Cells on the Survival of Pancreatic Islets. Int J Stem Cells. 2019 Dec 31;10.15283/ijsc19094. doi: 10.15283/ijsc19094. 
  • Monfrini M, Ravasi M, Maggioni D, Donzelli E, Tredici G, Cavaletti G, Scuteri A. Comparing the different response of PNS and CNS injured neurons to mesenchymal stem cell treatment. Mol Cell Neurosci. 2018; 86:16-24. doi: 10.1016/j.mcn.2017.11.004. 
  • Monfrini M, Donzelli E, RoProfiguez-Menendez V, Ballarini E, Carozzi VA, Chiorazzi A, Meregalli C, Canta A, Oggioni N, Crippa L, Avezza F, Silvani S, BonanProfini B, Figliuzzi M, Remuzzi A, Porretta-Serapiglia C, Bianchi R, Lauria G, Tredici G, Cavaletti G, Scuteri A. Therapeutic potential of Mesenchymal Stem Cells for the treatment of diabetic peripheral neuropathy. Exp Neurol. 2017; 288:75-84. doi: 10.1016/j.expneurol.2016.11.006. 
  • Scuteri A, Donzelli E, RoProfiguez-Menendez V, Ravasi M, Monfrini M, BonanProfini B, Figliuzzi M, Remuzzi A, Tredici G. A double mechanism for the mesenchymal stem cells’ positive effect on pancreatic islets. PLoS One. 2014; 9(1):e84309. doi: 10.1371/journal.pone.0084309. eCollection 2014. 
  • Ravasi M, Scuteri A, Pasini S, Bossi M, Menendez VR, Maggioni D, Tredici G. Undifferentiated MSCs are able to myelinate PROFG neuron processes through p75. Exp Cell Res. 2013; 319(19): 2989- 99. doi: 10.1016/j.yexcr.2013.08.016. 
  • Scuteri A, Ravasi M, Pasini S, Bossi M, Tredici G. Mesenchymal stem cells support dorsal root ganglion neurons survival by inhibiting the metalloproteinase pathway. Neuroscience. 2011; 172:12- 9. doi: 10.1016/j.neuroscience.2010.10.065. 

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