Ildebrando Appollonio


Neurologist, born in Brescia (1960), Director of the Residency School in Neurology (since 2012), Associate Professor of Neurology (since 2005) at the University of Milano Bicocca, Chief of the Center for Memory and Cognitive Disorders (since 1999) and Clinical Associate (since 1990) at the Neurological Section, San Gerardo Hospital, A.S.S.T. Monza & Brianza where he carries out all his clinical and research activities.

Member of the Ethic Committee at the IRCCS “S. Maria Nascente”, Don Gnocchi Foundation in Milan as expert clinician (since 2013) and Member of the Neuroscience Center NeuroMi (since 2014)

Teaching duties are summarized on the Unimib website where European CV is additionally available 

Publications (as of 31.05.2021):  138 full papers on peer-reviewed journals (as author or co-author) (

Bibliometric Indexes:

– Total IF > 500

– H-index: 36 (since 2016: 20)

– Citations: 5700 (since 2016: 1900)

– Sources




  • Ultera-short psychometric tests for first level screening of cognitive decline
  • Instrumental biomarkers in Alzhemer’s disease (AD) and Mild cognitive impairment (MCI)
  • Phenotypic and instrumental characterization of the Progressive Posterior Cognitive Syndrome
  • Cognitive profile of Parkinson’s disease and parkinsonian dementias
  • Cognitive and behavioural characterization and muscular echography in Amyotrophic Lateral Sclerosis (ALS)
  • Case reports and neurological semeiology

More details at


Two research lines are pursued within the Ph.D. program

Instrumental biomarkers in Alzheimer’s disease and mild cognitive impairment

This research project evalautes the role of instrumental biomarkers in two different cognitive conditions: early diagnosis of Alzheimer’s dementia and prognostic value in subjects with mild cognitive impairment. Specifically, the following instrumental biomarkers will be used:

  • Brain PET with 18F-Flutemetamol to study amyloid fibrils deposition, in collaboration with the Nuclear Medicine Dept. (prof. C. Messa, dr. M. Musarra).
  • NMR brain imaging with a series of novel sequences in collaboration with the Neuroradiology Health Physics Services (dr. M. Patassini).

 Phenotypic and instrumental characterization of Progressive Posterior Cognitive Syndrome

The label of Progressive Posterior Cognitive Syndrome (PPCS) is applied to various clinical conditions characterized by the progressive decline of visuo-spatial abilities, apraxia and agnosia with a concomitant relative sparing of both memory and anterior cognitive domains. The neuropathological bases of these conditions are equally heterogeneous: Alzheimer’s disease, especially in case of Posterior Cortical Atrophy, Cortico-Basal Degeneration, Lewy Body Dementia. Aim of the present project is to better characterize PPCS at both the phenotypic and the instrumental biomarkers level.



1: Storti B, Diamanti S, Tremolizzo L, Riva N, Lunetta C, Filippi M, Ferrarese C, Appollonio I. ALS Mimics due to Affection of the Cervical Spine: From Common Compressive Myelopathy to Rare CSF Epidural Collection. Case Rep Neurol. 2021 Mar 4;13(1):145-156. doi: 10.1159/000512810. PMID: 33790773; PMCID: PMC7989791.

2: Tremolizzo L, Bargossi L, Storti B, Ferrarese C, Bellelli G, Appollonio I. Delirium in your house: a survey during General Practitioner-programmed home visits. Aging Clin Exp Res. 2021 Feb 18:1–5. doi: 10.1007/s40520-021-01806-1. Epub ahead of print. PMID: 33604822; PMCID: PMC7891467.

3: Beretta S, Da Re F, Francioni V, Remida P, Storti B, Fumagalli L, Piatti ML, Santoro P, Cereda D, Cutellè C, Pirro F, Montisano DA, Beretta F, Pasini F, Cavallero A, Appollonio I, Ferrarese C. Case Report: Concomitant Massive Cerebral Venous Thrombosis and Internal Iliac Vein Thrombosis Related to Paucisymptomatic COVID-19 Infection. Front Neurol. 2021 Feb 10;12:622130. doi: 10.3389/fneur.2021.622130. PMID: 33643200; PMCID: PMC7902908.

4: Conti E, Sala G, Diamanti S, Casati M, Lunetta C, Gerardi F, Tarlarini C, Mosca L, Riva N, Falzone Y, Filippi M, Appollonio I, Ferrarese C, Tremolizzo L. Serum naturally occurring anti-TDP-43 auto-antibodies are increased in amyotrophic lateral sclerosis. Sci Rep. 2021 Jan 21;11(1):1978. doi: 10.1038/s41598-021-81599-5. PMID: 33479441; PMCID: PMC7820419.

5: Frederiksen KS, Nielsen TR, Appollonio I, Andersen BB, Riverol M, Boada M, Ceccaldi M, Dubois B, Engelborghs S, Frölich L, Hausner L, Gabelle A, Gabryelewicz T, Grimmer T, Hanseeuw B, Hort J, Hugon J, Jelic V, Koivisto A, Kramberger MG, Lebouvier T, Lleó A, de Mendonça A, Nobili F, Ousset PJ, Perneczky R, Olde Rikkert M, Robinson D, Rouaud O, Sánchez E, Santana I, Scarmeas N, Sheardova K, Sloan S, Spiru L, Stefanova E, Traykov L, Yener G, Waldemar G. Biomarker counseling, disclosure of diagnosis and follow-up in patients with mild cognitive impairment: A European Alzheimer’s disease consortium survey. Int J Geriatr Psychiatry. 2021 Feb;36(2):324-333. doi: 10.1002/gps.5427. Epub 2020 Sep 16. PMID: 32896040.

6: Alberti P, Beretta S, Piatti M, Karantzoulis A, Piatti ML, Santoro P, Viganò M, Giovannelli G, Pirro F, Montisano DA, Appollonio I, Ferrarese C. Guillain- Barré syndrome related to COVID-19 infection. Neurol Neuroimmunol Neuroinflamm. 2020 Apr 29;7(4):e741. doi: 10.1212/NXI.0000000000000741. PMID: 32350026; PMCID: PMC7217652.

7: Francioni V, Pirro F, D’Anna G, Cairo M, Appollonio I, Ferrarese C, Tremolizzo L. DWI/FLAIR Mismatch during Hyperacute Infarction of the Percheron Artery: Time Is Thalamus! Case Rep Neurol. 2020 Mar 31;12(1):127-130. doi: 10.1159/000506416. PMID: 32308608; PMCID: PMC7154235.

8: Isella V, Rosazza C, Gazzotti M, Sala J, Morzenti S, Crivellaro C, Appollonio IM, Ferrarese C, Luzzatti C. A Metabolic Imaging Study of Lexical and Phonological Naming Errors in Alzheimer Disease. Am J Alzheimers Dis Other Demen. 2020 Jan-Dec;35:1533317520922390. doi: 10.1177/1533317520922390. PMID: 32356456.

9: Tremolizzo L, Lizio A, Santangelo G, Diamanti S, Lunetta C, Gerardi F, Messina S, La Foresta S, Riva N, Falzone Y, Filippi M, Woolley SC, Sansone VA, Siciliano M, Ferrarese C, Appollonio I; ALS-CBS Italian Study Group. ALS Cognitive Behavioral Screen (ALS-CBS): normative values for the Italian population and clinical usability. Neurol Sci. 2020 Apr;41(4):835-841. doi: 10.1007/s10072-019-04154-1. Epub 2019 Dec 5. PMID: 31807998.

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