Paola Marmiroli

CURRICULUM VITAE 

Paola Marmiroli was born in Milan and lives in Monza. 

  • 1984: MD, with honours, University of Milan 
  • 1988 : Board in Neurology, with honours, University of Milan 
  • 1989 – 2001:  Clinical neurologist at the Neurological Department of Vimercate General Hospital, Vimercate (Milan)
  • April 2001 – 2009: Assistant Professor in Human Anatomy at the School of Medicine and Surgery of the University of Milano-Bicocca, Milan.
  • October 2019 – present: Associate Professor in Human Anatomy at the Department of Biotechnology and Biosciences (BtBs) of the University of Milano-Bicocca, Milan

TEACHING ACTIVITY

  • 2001 – present: Human Anatomy for Medical students (MD Program) at the School of Medicine and Surgery, University of Milano-Bicocca
  • 2015 – present: Human Anatomy for Dental Surgery students (DDS Program) at the School of Medicine and Surgery, University of Milano-Bicocca
  • 2009 – 2017: Human Anatomy for Bachelor’s degree in Nursing and Midwifery 
  • 2008 – present : Neuroanatomy for Residency Program in Neurology and Neuropsychiatry – University of Milano-Bicocca
  • 2016-2017: Human Anatomy for Master in Wound Care, University of Milano-Bicocca
  • 2014-2015 and 2016-2017: Director of Master in Osteopathic Sciences, University of Milano-Bicocca 

RESEARCH ACTIVITY

Morphological studies in the field of neuroanatomy, immunohistochemical studies in peripheral nervous system pathology, research in neurotoxicity of anticancer drugs in animal models. Study of neuropathological changes of the central nervous system in metabolic, immunological and inflammatory diseases.

Recent and current activity:

  • Study of neurotoxicity of anticancer drugs on peripheral nervous system: collaboration in developing  new in vivo and in vitro animal models of chemotherapy-induced peripheral neuropathies  to understand their pathogenesis and to test neuroprotective compounds. The experience in the use of morphological methods is particularly applied in these studies.
  • Study of the neuropathological changes  in animal models of metabolic disease and of multiple sclerosis (EAE).
  • Study of Neuroinflammation in aging
  • Study on the effect of particulate matter in cardiovascular and neurodegeneration

PhD Program in Neuroscience – University of Milano-Bicocca

2002 – present: Member of the Academic Board – University of Milano-Bicocca 

Since 2020 : deputy coordinator

GRANTS OBTAINED AS PRINCIPAL INVESTIGATOR

  • Three grants from Fondazione Banca del Monte di Lombardia (2014-2017)

Project title: “Pre-clinical study on the mechanisms of neurotoxicity of cancer chemotherapy”

  • Grant from Fondazione Cariplo (2014-2018)

Project title: “Understanding the pathogenesis of oxaliplatin-induced peripheral neurotoxicity” 

  • FFABBR_NAT– Grant for research activity  –  2017-NAZ-0335 

INTERNATIONAL  ACADEMIC COLLABORATIONS

  • Centre for pain studies – University of Maryland, Baltimore, MD, USA  (Prof. S. Dorsey)
  • Department of Internal Medicine D and Interdisciplinary Center for Clinical Research (IZKF), University Hospital Münster, Münster, Germany (Prof. G. Ciarimboli)
  • Johns Hopkins University, Baltimore, MD (Prof. D. Cornblath, Prof. A. Hoke, Dr. B. Slusher)

PUBLICATIONS

Author of about 80 papers on international peer-reviewed journals.

Scopus H-index = 28

Scopus Author ID: 6603570341

ORCID Id: http://orcid.org/0000-0002-7590-7649

SELECTED PUBLICATIONS

  1. Milani C, Farina F, Botto L, Massimino L, Lonati E, Donzelli E, Ballarini E, Crippa L, Marmiroli P, Bulbarelli A, Palestini P.  Systemic Exposure to Air Pollution Induces Oxidative Stress and Inflammation in Mouse Brain, Contributing to Neurodegeneration Onset. Int J Mol Sci. 2020 May 24;21(10):E3699. doi: 10.3390/ijms21103699.PMID: 32456361
  2. Meregalli C, Fumagalli G, Alberti P, Canta A, Chiorazzi A, Monza L, Pozzi E, Carozzi VA, Blennow K, Zetterberg H, Cavaletti G, Marmiroli P.  Neurofilament light chain: a specific serum biomarker of axonal damage severity in rat models of Chemotherapy-Induced Peripheral Neurotoxicity. Arch Toxicol. 2020 Apr 24. doi: 10.1007/s00204-020-02755-w. Online ahead of print.PMID: 32333051
  3. Meregalli C, Marjanovic I, Scali C, Monza L, Spinoni N, Galliani C, Brivio R, Chiorazzi A, Ballarini E, Rodriguez-Menendez V, Carozzi VA, Alberti P, Fumagalli G, Pozzi E, Canta A, Quartu M, Briani C, Oggioni N, Marmiroli P, Cavaletti G. High-dose intravenous immunoglobulins reduce nerve macrophage infiltration and the severity of bortezomib-induced peripheral neurotoxicity in rats. J Neuroinflammation. 2018 Aug 21;15(1):232. doi: 10.1186/s12974-018-1270-x.PMID: 30131066 
  4. Marmiroli P, Riva B, Pozzi E, Ballarini E, Lim D, Chiorazzi A, Meregalli C, Distasi C, Renn CL, Semperboni S, Morosi L, Ruffinatti FA, Zucchetti M, Dorsey SG, Cavaletti G, Genazzani A, Carozzi VA. Susceptibility of different mouse strains to oxaliplatin peripheral neurotoxicity: Phenotypic and genotypic insights. PLoS One. 2017 Oct 11;12(10):e0186250. doi: 10.1371/journal.pone.0186250. eCollection 2017.PMID: 29020118 
  5. Canta A, Chiorazzi A, Carozzi VA, Meregalli C, Oggioni N, Bossi M, Rodriguez-Menendez V, Avezza F, Crippa L, Lombardi R, de Vito G, Piazza V, Cavaletti G, Marmiroli P. Age-related changes in the function and structure of the peripheral sensory pathway in mice. Neurobiol Aging. 2016 Sep;45:136-148. doi: 10.1016/j.neurobiolaging.2016.05.014. Epub 2016 May 20.PMID: 27459934
  6. Quartu M, Carozzi VA, Dorsey SG, Serra MP, Poddighe L, Picci C, Boi M, Melis T, Del Fiacco M, Meregalli C, Chiorazzi A, Renn CL, Cavaletti G, Marmiroli P. Bortezomib treatment produces nocifensive behavior and changes in the expression of TRPV1, CGRP, and substance P in the rat DRG, spinal cord, and sciatic nerve. Biomed Res Int. 2014;2014:180428. doi: 10.1155/2014/180428. Epub 2014 Apr 27.PMID: 24877063
Elisabetta Donzelli
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