CURRICULUM
Born in Milan on 29/04/1989. I obtained the Bachelor Degree in Pharmaceutical Biotechnology in March 2014 at the University of Milan. During the thesis internship, I gained experience in performing behavioral tests and pharmacological treatments in rats. I graduated in Biotechnology in Medicine in 2017 at the University of Milan – Bicocca (Monza), focusing my thesis on the analysis of the possible protective role of natural compounds on beta amyloid cytotoxicity and the intracellular signal transduction in human cell models.
From November 2017 I attended the PhD in Neurosciences at the University of Milan – Bicocca, studying the possible positive effects of natural extracts on beta-amyloid-induced cytotoxicity and neuroinflammation in human peripheral and central cell models.
RESEARCH PROJECT
Potential role of natural extracts against Aβ cytotoxicity and neuroinflammation
Track: Experimental Neuroscience
Tutor: Carlo Ferrarese
Supervisor: Chiara Paola Zoia
Alzheimer’s disease (AD) is characterized by deposition of amyloid beta peptide (Aβ) plaques and intracellular neurofibrillary tangles, glutamate excitotoxicity and loss of neurons. Aβ-induced oxidative stress plays an important role in AD. Soluble oligomers are the most toxic species of Aβ and they induce cognitive deficit in AD patients. Aβ interacts with several intracellular signals, in particular PI3K/AKT and MAPK, which are also involved in modulation of autophagy, apoptosis and in Aβ and Tau processing. In the last years much attention has been focused on the potential role of using natural compounds, in particular hop and coffee, as neuroprotective agents to attenuate or suppress inflammation, oxidative stress and Aβ-mediated cytotoxicity. Hop contains flavonoids, aromatic molecules which have antioxidant, antinflammatory and antiatherogenic properties. Hop extract has anti-aggregating effects on Aβ and seems to prevent its production in cultured cells. Coffee has antioxidant properties and may have a protective role against cognitive deterioration, too.
In this project will be investigated the potential protective role of coffee and hop against Aβ toxicity in human cellular models. The anti-oxidant/inflammatory properties of hop and coffee extracts and their involvement in kinase signalling, autophagy, apoptosis regulation, APP cleavage and Tau hyperphosphorylation will be assessed. Correlation among inflammation, oxidative stress and glutamate excitotoxicity (glutamate uptake) will be also evaluated.
RECENT PUBLICATIONS AND CONGRESSES
Publications
- Musazzi, G. Treccani, M. Milanese, C. Perego, N. Nava, P. Tornese, N. Sala, C. Bazzini, A. Malgaroli, J. Nyengaard, G. Wegener, G. Bonanno, M. Popoli. The stress impact on synaptic function and brain architecture: a key to mood and anxiety disorders. (2015) DOI: http://dx.doi.org/10.1016/S0924-977X(15)30105-X
- N. Sala, L. Musazzi, P. Tornese, C. Bazzini, M. Popoli. Chronic treatment with desipramine blocks the time-dependent effects of acute stress on working memory. (2017) DOI: http://dx.doi.org/10.1016/S0924-977X(17)30115-3
- F. La Rosa, M. Saresella, I. Marventano, F. Piancone, E.Ripamonti, N. Al-Daghri, C. Bazzini, C.P. Zoia, E. Conti, C. Ferrarese, M. Clerici. Stavudine Reduces NLRP3 Inflammasome Activation and Modulates Amyloid-β Autophagy. J Alzheimers Dis. 2019 Sep 30. doi: 10.3233/JAD-181259.
- Gironi M, Dalla-Costa G, Frigo M, Rovaris M, Clerici M, Bazzini C, Andreoni S, Comi G, Furlan R, Ferrarese C, Cavaletti G, Saresella M, Zoia CP.
Platelet glutamate uptake and Th1 cells inversely correlate in relapsing/remitting and in progressive multiple sclerosis. Multiple Sclerosis and Related Disorders, Accepted 2020 Feb 10. https://doi.org/10.1016/j.msard.2020.102007
Congresses
- Bazzini C, Sala G, Bolognini A, Airoldi C, Ciaramelli C, Palmioli A, Ferrarese C, Zoia CP “Potential role of Hop and Coffee against amyloid beta toxicity”. 5th NeuroMI International Meeting – Food for Brain: promoting health and preventing diseases. Università di Milano-Bicocca. Milan, 20-22 November 2019
- Bazzini C, La Rosa F, Conti E, Clerici M, Ferrarese C, Saresella M and Zoia CP. “Stavudine inhibits inflammasome down-regulating Ras and GSK/PI3K pathways in amyloid-beta treated THP-1 cells”. XIV Convegno Nazionale SINdem. Florence 7-9 March 2019
- Bazzini C, Conti E, Tremolizzo L, Cereda D, Isella V, Ferrarese C and Zoia CP. “Modulation of MAP-Kinase and PI3K/AKT signaling pathways in fibroblasts from Alzheimer’s Disease patients”. 4th NeuroMI International Meeting – International Conference Brain Stimulation and Brain Plasticity: from Basic Research to Clinical Practice. University of Milano-Bicocca. Milan, 21-23 November 2018
- Zoia CP, Frigo M, Bazzini C, Andreoni S, Fusco ML, Gironi M, Ferrarese C and Cavaletti GA. Modulation of glutamate transport in platelets from Multiple Sclerosis patients. Poster presented at International Symposium Personalised Medicine in Multiple Sclerosis, Università di Milano-Bicocca. Milan, 13-15 September 2017
- Bazzini C, Sala G, Airoldi C, Palmioli A, Bruzzone C, Ferrarerse C, Zoia CP. Signal transduction and β-amyloid cytotoxicity in human fibroblasts: Hop protective role? Poster presented at NeuroMi Annual Meeting 2017
- C.P. Zoia, C. Bazzini, E. Conti, L. Tremolizzo, C. Ferrarese. SiTraNeD: signal transduction on neurodegenerative diseases in peripheral models. Poster presented at International Symposium on Neurobiology Joint Meeting University of Milano Bicocca-University of Surrey January 31, 2017 U6 Building, Martini room Piazza Ateneo Nuovo, 1 Milano – Italy
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