Giulia Fumagalli

CURRICULUM

Giulia Fumagalli obtained her Bachelor’s degree in Biotechnology in 2012 and her master degree in Medical Biotechnology in 2015 at the University of Milano-Bicocca.

She works on in vivo research projects regarding Chemotherapy-Induced Peripheral Neurotoxicity at the Experimental Neurology Unit (University of Milano-Bicocca), where she currently is Ph.D. student in Neuroscience.

Her main skills are in the development and use of in vivo experimental models to study the peripheral neuropathies.

RESEARCH PROJECT

The role of the immune system in different animal models of Oxaliplatin Induced Peripheral Neurotoxicity.

  • Tutor: Guido Cavaletti
  • Track: Experimental Neuroscience

Oxaliplatin (OHP) is a third-generation platinum-based chemotherapy agent commonly used for colorectal cancer. Despite its efficacy, it causes various forms of side effects, especially peripheral neurotoxicity (OIPN). No cure is aviable: the mechanisms of OIPN are not completely understood and should be studied.

OIPN consists of two main clinical manifestations: acute and chronic ones. Acute phenomena, such as transient paresthesia at limb extremities and cramps, appear during or shorter after OHP administration and lasting 24-72 hours. These symptoms are induced by cold exposure and caused by axonal hyperexcitability.

Chronic neurotoxicity is a dose-dependent side effect characterized by a painful neuropathic syndrome, which can lead to discontinuation of chemotherapy.

An emerging concept is that neuroinflammation is one of the major mechanisms underlying chemotherapy-induced peripheral neurotoxicity: studies in different animal models suggest an involvment of the neuroimmune signalling and an increase in pro-inflammatory cytokine expression in the establishement of neuropathic pain.

In this study a possible involvement of the immune response in animal models of Oxaliplatin induced neurotoxicity and neuropathic pain will be evaluated, examining different schedules of treatment in different mice models.

RECENT PUBLICATIONS AND CONGRESSES

Publications

Congresses

  • Fumagalli, G; Meregalli, C; Alberti, P; Carozzi, V; Ballarini, E; Sandelius, A; Blennow, K; Zetterberg, H; Cavaletti, G. Blood NfL as a potential axonal damage marker in different CIPN rat models. Peripheral Nerve Society (PNS) Annual Meeting. 22-25 Luglio 2018, Baltimore, USA. POSTER
  • Fumagalli, G., Meregalli, C., Monza, L., Alberti, P., Pozzi, E., Carozzi, V., et al. (2018). Blood neurofilament light chains as a potential damage marker in chemotherapy-induce peripheral neuropathy rodent models. Eight Annual Meeting of the Associazione Italiana per lo studio del Sistema Nervoso Periferico (ASNP), Roma. PRESENTAZIONE ORALE
  • Fumagalli G, Chiorazzi A, Meregalli C, Carozzi VA, Monza L, Pozzi E, Alberti P, Goss J, Krisky D, Wechuck J, Marmiroli P, Cavaletti G . Evaluation of the Efficacy of PeriphaGen Neurotrophin-3 Expressing Vector for Oxaliplatin Induced Peripheral Neuropathy. XLVII Congresso della Società Italiana di Neurologia SIN. 22-25 Ottobre 2016, Venezia. POSTER
  • Alberti P, Fumagalli G, Monza L, Cavaletti G. EMG recordings at rest to verify axonal hyperexcitability in a rat model of oxaliplatin induced peripheral neurotoxicity. Seventh Annual Meeting of the Associazione Italiana per lo studio del Sistema Nervoso Periferico (ASNP). 20-22 Aprile 2017, Bergamo.
  • Alberti P, Fumagalli G, Monza L, Pozzi E, Cavaletti G. Accurate neurophysiological monitoring for sensory neuropathy in mouse models of chemotherapy induced peripheral neurotoxicity. Seventh Annual Meeting of the Associazione Italiana per lo studio del Sistema Nervoso Periferico (ASNP). 20-22 Aprile 2017, Bergamo.
  • Chiorazzi A,  Meregalli C, Oggioni N, Canta A,  Carozzi VA, Fumagalli G, Pozzi E, Rodriguez Menendez V,  Marmiroli P, Pietra C, Cavaletti G. Effect of preventive and therapeutic treatment of ghrelin agonist HM01 on the peripheral neurotoxicity induced by bortezomib in wistar rats. Seventh Annual Meeting of the Associazione Italiana per lo studio del Sistema Nervoso Periferico (ASNP). 20-22 Aprile 2017, Bergamo.
  • Alberti P, Fumagalli G, Monza L, Cavaletti G. Advanced neurophysiology – A translational approach to neuropathy and neuropathic pain. International Symposium of Neurobiology. 31 Gennaio 2017, Milano.
  • Chiorazzi A,  Meregalli C, Canta A,  Carozzi VA, Oggioni N, Rigolio R, Pozzi E, Monza L, Fumagalli G,  Alberti P, Marmiroli P, Cavaletti G. Multimodal experimental approach to the study of human neurological diseases. International Symposium of Neurobiology. 31 Gennaio 2017, Milano.
  • Monza L, Fumagalli G, Alberti P, Oggioni N, Dondio M, Spinoni N, Galliani C, Brivio R, Marjanovic I, Scali C, Meregalli C. Pharmacokinetics of ivig in wistar rats. XXIII SYMPOSIUM Associazione Italiana per le Scienze degli Animali da Laboratorio AISAL. Modelli animali e modelli alternativi: quale future per la ricerca? 10-11 Ottobre 2016, Roma.
  • Fumagalli G, Chiorazzi A, Meregalli C, Carozzi VA, Monza L, Pozzi E, Alberti P, Goss J, Krisky D, Wechuck J, Marmiroli P, Cavaletti G . Evaluation of the Efficacy of PeriphaGen Neurotrophin-3 Expressing Vector for Oxaliplatin Induced Peripheral Neuropathy. XLVII Congresso della Società Italiana di Neurologia SIN. 22-25 Ottobre 2016, Venezia.
  • Paola Alberti, Giulia Fumagalli, Laura Monza, Guido Cavaletti. How to assess models of oxaliplatin induced peripheral neurotoxicity – A neurophysiological translational approach. XLVII Congresso della Società Italiana di Neurologia SIN. 22-25 Ottobre 2016, Venezia.
  • Krystyna M.  Wozniak, Ying Wu, Ying Liu, Rachel Weinberg, Valentina Carozzi, Giulia Fumagalli, Paola Alberti, Brett Cook, Sarah Benbow, Bruce A. Littlefield, Kenichi Nomoto, Les Wilson, MaryAnn Jordan, Stu Feinstein, Guido Cavaletti, Joseph Mankowski, Michael Polydefkis, and Barbara S. Slusher.
  • Long-term recovery from chemotherapy-induced neuropathy following paclitaxel, ixabepilone, eribulin and vinorelbine in mice. 64th Meeting SfN Society for Neuroscience. November 12-16, San Diego (California).
  • Paola Alberti, Giulia Fumagalli, Guido Cavaletti. Translational comprehensive approach to chemotherapy induced peripheral neurotoxicity – neurophysiology as the link between bench and bedside. Second International Meeting of the Milan Centre for Neuroscience NEUROMI. 6-8 Luglio 2016, Università di Milano Bicocca, Milano.
  • Paola Alberti, Giulia Fumagalli, Guido Cavaletti, Carlo Ferrarese, Ildebrando  Appollonio. Oxaliplatin induced peripheral neurotoxicity – a neurophysiological translational approach. 5° Giornata dello specializzando in Neurologia. 14 Giugno 2016, Università degli studi di Milano, Milano.
  • Sara Semperboni, Valentina Carozzi, Beatrice Riva, Eleonora Pozzi, Giulia Fumagalli, Guido Cavaletti, Armando Genazzani, Paola Marmiroli. The severity of oxaliplatin neurotoxicity is related to differential expression of a solute transporter in mice. 2nd Edition – European Meeting of Neuroscience by PhD Students. 29 Aprile 2016, Grenoble (France).
  • Ceresa C, Nicolini G, Semperboni S, Fumagalli G, Pellei M, Margiotta N, Gandin V, Hoeschele J.D, Santini C, Cavaletti G. In vitro neurotoxicity of new promising metalbased anticancer complexes. Sesta Riunione Annuale dell’Associazione italiana per lo studio del Sistema Nervoso Periferico. 14-16 Aprile 2016, Mondello (Palermo).
  • Chiorazzi A, Carozzi VA, Meregalli C, Ceresa C, Fumagalli G, Monza L, Oggioni N, Crippa L, Marmiroli P, Cavaletti G. A possible role of oct2 gene in the development of peripheral neurotoxicity induced by cisplatin. Sesta Riunione Annuale dell’Associazione italiana per lo studio del Sistema Nervoso Periferico. 14-16 Aprile 2016, Mondello (Palermo).
  • Arianna Scuteri, Marianna Monfrini, Giulia Fumagalli, Virginia Rodriguez-Menendez, Mario Bossi, Giovanni Tredici, Guido Cavaletti.  Making connections: gap junctions are pivotal for MSC-induced long lasting survival of sensory neurons. 69° CONGRESSO NAZIONALE SIAI Società Italiana di Anatomia e Istologia. 17 – 19 Settembre 2015, Ferrara.

FURTHER INFO

To get further details and the full pub list, visit the ORCID website.

Elisabetta Donzelli
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