Giulia Terribile

Curriculum Vitae 

Born on September the 2nd, 1993, she achieved a single-cycle master’s degree in Pharmacy and Industrial Pharmacy (LM-13) at University of Milan in May 2018 and she obtained the qualification to practice the profession of Pharmacist in July 2018. From March 2017 to May 2018 she carried out her internship at the Institute of Neuroscience at the Department of Medical Biotechnology and Translational Medicine of the Consiglio Nazionale delle Ricerche (CNR) of Milan where she was involved in the characterization of the metabolism of microglia with different phenotypes. From October 2018 to October 2019 she worked as an internship fellow at the IRCCS -Istituto di Ricerche Farmacologiche Mario Negri, where she was involved in characterizing the role of p97 in muscle atrophy induced by different causes including amyotrophic lateral sclerosis (ALS).

Since November 2019 she has been a student of the PhD program in Experimental Neuroscience at the School of Medicine & Surgery of the University of Milano-Bicocca, in the Physiology Laboratory of Professor Giulio Alfredo Sancini. 

Her aim is to explore, through imaging and electrophysiological techniques, the effects of environmental particulate on the central nervous system, with focus on microglia, the main effector of neuroinflammation, and on the several neurophysiological processes modulation.

PhD Research project

Air pollution, neuroinflammation and synaptic dysfunction 

  • Curriculum: Experimental Neuroscience
  • Tutor: Giulio Alfredo Sancini

About two decades ago, the central nervous system (CNS) has been proposed to be a target organ for the detrimental effects of airborne pollutants (Oberdorster and Utell, 2002). Emerging evidence from epidemiological, clinical, and experimental studies suggests that certain neurological diseases, such as Alzheimer’s disease (AD) and Parkinson’s disease (PD), may be strongly associated with air pollution (Tonelli and Postolache, 2012; Block et al., 2012; Davis et al., 2013; Hartz et al., 2008). Although the exact mechanisms underlying brain pathologies are not fully understood, environmental pollution is believed to exert its neurotoxic function through the processes of oxidative stress, glial activation, cerebro-vascular damage and neuroinflammation, which are also implicated in the etiopathogenesis of neurodegenerative diseases (Costa et al., 2014).  In this project, studies will be performed to explore the effects of airborne pollution on CNS elements and homeostasis. In particular, we will explore PM effects on microglia, brain cells of nonneural origin, as predominant regulators of neuroinflammation, recurring hallmarks of neurodegenerative diseases. Furthermore, we will investigate the interaction of PM with neuronal activity, especially evaluating whether the PM can act, increasing or decreasing, different neurophysiological processes such as neuro-transmitter release and synaptic plasticity.

Research activity

 Poster

  • Giulia Terribile, Andrea David Re Cecconi, Giorgio Aquila, Andrea Degiorgi, Mara Forti and Rosanna Piccirillo “Dissecting the possible role of p97 in muscle wasting during cancer”. Poster presentation at the 16th IIM Meeting 2019 which took place in Assisi, Italy, (October 2019).
  • Giorgio Aquila, Andrea David Re Cecconi, Giulia Terribile, Roberta Frapolli, Ezia Bello, Deborah Novelli, Lidia Staszewsky, Roberto Latini, Maurizio D’Incalci, Rosanna Piccirillo “Lurbinectedin delays the onset of splenomegaly and extends survival of C26 tumor–bearing mice “. Poster presented at the 16th IIM Meeting 2019 which took place in Assisi, Italy, (October 2019).
  • Giulia Terribile, Andrea David Re Cecconi, Giorgio Aquila, Andrea Degiorgi, Mara Forti and Rosanna Piccirillo “Dissecting the possible role of p97 in muscle wasting during cancer cachexia”. Poster presentation at the PhD Students Meeting 2019, which took place at Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy, (June 2019).

Workshops 

  • Fifth Neuromi International meeting “Food for Brain: promoting health and preventing diseases” Milan, November 2019
  • IIM Meeting 2019, Assisi, October 2019. 
  • PhD Students Meeting Milan, June 2019

Others 

Co-Chair at “session 7: Therapeutic approaches for muscle diseases.” at the 16th IIM Meeting 2019 which took place in Assisi, Italy, (October 2019). 

Further information

Elisabetta Donzelli
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