CURRICULUM VITAE

Giovanni Tredici was born in Milan in 1944.
MD (Milano, I, 1969); register in neurology (Milano, I, 1972); Assistant neurologist (1970-1983); Associated Professor of Anatomy (Milano, I, 1983-1985); Full Professor of Neuroanatomy, faculty of Medicine, University of Milan; MURST advisor for the national research project “Neurobiologia”.
Director of the Dep.of Neuroscience and Biomedical Technologies, Milano Bicocca (2000-2012)
President of the Doctoral School in Experimental and Clinical Medical Science (2010-now)

RESEARCH ACTIVITY

• Ultrastructural organization and synaptic connections of brain stem and thalamic nuclei involved in pain transmission or in electrical cortical rhythms.
• Neuropatology of peripheral nerves. In particular, toxic and drug induced peripheral neuropathies.
• Cellular responses to different kinds of stimuli in neuronal-like cells (neuroblastoma).
• Mesenchimal Stem cells : biological characterization and use in reparative medicine .
• Animal models of neuroimmunological diseases.

Tecniques: morphometry, electron microscopy, immunoistochemistry, anterograde neuronal tracers, cellular cultures, PCR, immunoblotting

PUBBLICATIONS

1. Ravasi M, Scuteri A, Pasini S, Bossi M, Menendez VR, Maggioni D, Tredici G. Undifferentiated MSCs are able to myelinate DRG neuron processes through p75. Exp Cell Res. 2013 Nov 15;319(19):2989-99
2. Redaelli S, Bentivegna A, Foudah D, Miloso M, Redondo J, Riva G, Baronchelli S, Dalprà L, Tredici G. From cytogenomic to epigenomic profiles: monitoring the biologic behavior of in vitro cultured human bone marrow mesenchymal stem cells. Stem Cell Res Ther. 2012 Nov 20;3(6):47
3. Scalabrino G, Veber D, Mutti E, Calligaro A, Milani S, Tredici G. Cobalamin (vitamin B(12)) regulation of PrP(C), PrP(C)-mRNA and copper levels in rat central nervous system. Exp Neurol. 2012 Jan;233(1):380-90
4. Donzelli E, Lucchini C, Ballarini E, Scuteri A, Carini F, Tredici G, Miloso M. ERK1 and ERK2 are involved in recruitment and maturation of human mesenchymal stem cells induced to adipogenic differentiation. J Mol Cell Biol. 2011 Apr;3(2):123-31
5. Scuteri A, Ravasi M, Pasini S, Bossi M, Tredici G. Mesenchymal stem cells support dorsal root ganglion neurons survival by inhibiting the metalloproteinase pathway. Neuroscience. 2011 Jan 13;172:12-9