Ioannis Ugo Isaias


Ioannis U. Isaias is Full Professor (tenured) of Neurology and Chief of the Motor Control and Neuroimaging research laboratory at the University Hospital of Würzburg. His research combines molecular brain imaging, biomechanics and deep brain stimulation (DBS), to describe abnormal functioning of brain networks in movement disorders (e.g., Parkinson’s disease, Essential tremor). Dr. Isaias received his MD from the University of Pavia and the University of Leipzig. After completing residency training in neurology at the University of Milano Bicocca, he pursued fellowship training at the Parkinson Institute of Milano and at the Mount Sinai Medical Center in New York. He then obtained a PhD in Human Physiology at the University of Milano. In 2016 Dr. Isaias was appointed Adjunct Professor of Neurology at the New York University – NYU Langone Health.


  • Movement disorders
  • Motor cortex, basal ganglia, subthalamic nucleus, locus coeruleus
  • Motor control and biomechanics
  • Molecular brain imaging (PET and SPECT)
  • Neuromodulation


  • Gait and balance disturbances
  • Tremor
  • Dyskinesia
  • Adaptive deep brain stimulation


    1. Gait-related frequency modulation of beta oscillatory activity in the subthalamic nucleus of parkinsonian patients. Canessa A, Palmisano C, Isaias IU, Mazzoni A. Brain Stimul. 2020 Nov-Dec;13(6):1743-1752. doi: 10.1016/j.brs.2020.09.006.
    2. Freezing of gait in Parkinson’s disease reflects a sudden derangement of locomotor network dynamics. Pozzi NG, Canessa A, Palmisano C, et al, Isaias IU. Brain. 2019 Jul 1;142(7):2037-2050. doi: 10.1093/brain/awz141
    3. Excitability of the supplementary motor area in Parkinson’s disease depends on subcortical damage. Casarotto S, Turco F, Comanducci A, et al, Isaias IU. Brain Stimul. 2019 Jan-Feb;12(1):152-160. doi: 10.1016/j.brs.2018.10.011
    4. Progressive gait ataxia following deep brain stimulation for essential tremor: adverse effect or lack of efficacy? Reich MM, Brumberg J, Pozzi NG, et al, Isaias IU. Brain. 2016 Nov 1;139(11):2948-2956. doi: 10.1093/brain/aww223.
    5. Parkinson’s disease in GTP cyclohydrolase 1 mutation carriers. Mencacci NE, Isaias IU, Reich MM, et al; International Parkinson’s Disease Genomics Consortium and UCL-exomes consortium. Brain.  2014 Sep;137(Pt 9):2480-92. doi: 10.1093/brain/awu179.


  • Charité – Universitätsmedizin Berlin (Berlin, Germany)
  • Politecnico di Milano (Milano, Italy)
  • Università degli Studi di Genova (Genova, Italy)
  • Scuola Superiore Sant’Anna (Pisa, Italy)
  • New York University – NYU Langone Health (New York, USA)
  • CUNY Medical School (New York, USA)


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