Marina del Puppo

CURRICULUM

  • 1980 Degree in Chemistry and Pharmaceutical Technologies;
  • 1980-1981 Research fellow at the Institute of Chemistry, School of Medicine, University of Milan;
  • from 1983 Researcher at the Department of Medical Chemistry and Biochemistry, School of Medicine, University of Milan;
  • from 1999 Researcher  at the Department of Experimental and Environmental Medicine and Biotechnology (DIMESAB) now Department of Medicine and Surgery (DMC) School of Medicine of the University of Milano-Bicocca.
  • 2005 Associate Professor of Biochemistry, School of Medicine, University of Milan-Bicocca.

RESEARCH TOPICS

Researches in progress include:

  • studies on changes in metabolism of oxysterols and neurosterols during aging and in neurodegenerative diseases
  • role of cholesterol transformation into oxysterols and regulation of bile acid synthesis in patients with metabolic syndrome and in obese subjects
  • metabolic studies using tracers labelled with stable isotopes to define the “in vivo” production in humans of endogenous compounds (bile acids).

MOST RELEVANT PUBLICATIONS

  1. Treatment of SPG5 with cholesterol-lowering drugs. Mignarri A, Malandrini A, Del Puppo M, Magni A, Monti L, Ginanneschi F, Tessa A, Santorelli FM, Federico A, Dotti MT. J Neurol. 2015 Dec;262(12):2783-5. doi: 10.1007/s00415-015-7971-5.
  2. Evaluation of cholesterol metabolism in cerebrotendinous xanthomatosis. Mignarri A, Magni A, Del Puppo M, Gallus GN, Björkhem I, Federico A, Dotti MT. J Inherit Metab Dis. 2016 Jan;39(1):75-83. doi: 10.1007/s10545-015-9873-1.
  3. Duodenal diverted sleeve gastrectomy with ileal interposition does not cause biliary salt malabsorption. Foschi DA, Rizzi A, Tubazio I, Conti L, Vago T, Bevilacqua M, Magni A, Del Puppo M. Surg Obes Relat Dis. 2015 Mar-Apr;11(2):372-6. doi: 10.1016/j.soard.2014.10.025
  4. Hereditary spastic paraplegia type 5: a potentially treatable disorder of cholesterol metabolism. Mignarri A, Malandrini A, Del Puppo M, Magni A, Monti L, Ginanneschi F, Tessa A, Santorelli FM, Federico A, Dotti MT. J Neurol. 2014 Mar;261(3):617-9. doi: 10.1007/s00415-014-7253-7.
  5. In vivo degradation of cholesterol to bile acids is reduced in patients receiving parenteral nutrition. Carulli L, Del Puppo M, Anzivino C, Zambianchi L, Gabbi C, Baldelli E, Odoardi MR, Loria P, Carulli N, Bertolotti M. JPEN J Parenter Enteral Nutr. 2014 Feb;38(2):220-6. doi: 10.1177/0148607113476751.
Elisabetta Donzelli
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