CURRICULUM
Born on 13th May 1991, I obtained my bachelor degree in Medical and Pharmaceutical Biotechnology in 2013 and after the Master degree in Neurobiology in 2015 (University of Pavia). Then I worked as a fellowship holder in Neuropsychopharmacology headed by Professor Flavia Valtorta (San Raffaele Hospital, Milan) where I performed in vivo electrophysiological recordings on murine model. From November 2016 I am Neuroscience PhD student (University Milan Bicocca) at Physiology Laboratory headed by Giulio Alfredo Sancini where my principal aim is to assess ex vivo and in vivo neurophysiological studies using electrophysiological and imaging techniques to evaluate nanoparticle action and their interaction with central nervous system (CNS) elements.
RESEARCH PROJECT
Neurophysiological studies to evaluate clinical potential of brain targeted nanoparticles
- Track: Neuroscienze Sperimentali
- Tutor: Giulio Sancini
Ex vivo and in vivo neurophysiological studies will be perform to evaluate nanoparticle (NPs) action and their interaction with central nervous system (CNS) elements. We will evaluate their possible effects on neuronal response (both evoked and spontaneous) and synaptic transmission studying neurons and their networks interaction in particular in cortex and hippocampus. The effect of NPs on neuronal side will be tested and we will assess if they have a role in modulating neurotransmitter release. We will further evaluate both ex vivo and in vivo, if NPs can modulate the synaptic plasticity.
WORKSHOPS ATTENDANCE
- January 31, 2017- “International Symposium on Neurobiology”, Università degli Studi di Milano Bicocca.
- February 16-17, 2017 – “La plasticità neuronale come strumento per la riabilitazione” at Humanitas (Rozzano, Milano).
- June 12, 2018 – Flow cytometry in experimental planning: something good to know
RECENT PUBLICATIONS AND CONGRESSES
Publications
- Zuccolo E, Kheder DA, Lim D, Perna A, Nezza FD, Botta L, Scarpellino G, Negri, S, Martinotti S, Soda T, Forcaia G, Riboni L, Ranzato E, Sancini G, Ambrosone L, D’Angelo E, Guerra G, Moccia F. Glutamate triggers intracellular Ca(2+) oscillations and nitric oxide release by inducing NAADP- and InsP(3) –dependent Ca(2+) release in mouse brain endothelial cells. J Cell Physiol. 2018 Nov 19. doi: 10.1002/jcp.26953. [Epub ahead of print] PubMed PMID: 30451297.
- Zuccolo E, Laforenza U, Negri S, Botta L, Berra-Romani R, Faris P, Scarpellino G, Forcaia G, Pellavio G, Sancini G, Moccia F. Muscarinic M5 receptors trigger acetylcholine-induced Ca(2+) signals and nitric oxide release in human brain microvascular endothelial cells. J Cell Physiol. 2018 Sep 7. doi: 10.1002/jcp.27234. [Epub ahead of print] PubMed PMID: 30191989.
- Aracri P, de Curtis M, Forcaia G, Uva L. Enhanced thalamo-hippocampal synchronization during focal limbic seizures. Epilepsia. 2018 Sep;59(9):1774-1784. doi: 10.1111/epi.14521. Epub 2018 Jul 23. PubMed PMID: 30039519.
Poster presentaions
- September 6-8, 2017- 68th SIF National Congress, Pavia
- September 13-15, 2017- Federation of European Physiological Societies (FEPS), Vienna.
- November 16-18, 2017- 21° Congresso nazionale SIRC-Imola
- June 29-30, 2018 – BraYn conference
- July 2, 2018 – Calcium Day, Novara
- July 11-15, 2018 – 12th FENS Forum of Neuroscience
- September 6-8, 2018 – 69th SIF National Congress, Firenze
- November 21-23, 2018 – Fourth NeuroMI International Meeting
MORE INFO
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