Lorenzo Diana

Lorenzo Diana

CURRICULUM

Nato a Verbania (VB), ho conseguito nel 2013 la Laurea Triennale in Scienze e Tecniche Psicologiche presso l’Università degli Studi di Milano-Bicocca e nel 2015 la Laurea Magistrale in Cognitive Neuroscience and Clinical Neuropsychology presso l’Università degli Studi di Padova sviluppando una tesi che indagava l’interazione tra attenzione visuo-spaziale e load cognitivo in pazienti con lesioni cerebrali all’emisfero sinistro. Dal 2016 al 2018 ho lavorato come assistente di ricerca sotto la supervisione del Prof. Dr. Med. René Mueri e del PD Dr. Dario Cazzoli presso l’Università di Berna ed il Dipartimento di Neurologia dell’Ospedale Universitario di Berna, Inselspital, prendendo parte a diversi progetti inerenti l’interazione tra attenzione spaziale e non spaziale, creatività e pensiero divergente. Da novembre 2018 sono studente del Dottorato in Neuroscienze Cliniche presso il Dipartimento di Medicina e Chirurgia dell’Università degli Studi di Milano Bicocca sotto la supervisione della Prof.ssa Nadia Bolognini. Il mio principale ambito di ricerca riguarda i meccanismi dell’attenzione spaziale e la loro modulazione tramite tecniche di stimolazione cerebrale non invasive (tES e TMS) in soggetti sani e pazienti con disturbi acquisiti dell’attenzione in seguito a lesione cerebrale.

PROGETTO DI RICERCA

Modulation of cortical networks of attention by means of non-invasive brain stimulation (NIBS) techniques combined with eye tracking

  • Curriculum: Neuroscienze Cliniche
  • Tutor: Nadia Bolognini

Aims:

The present project aims to investigate the efficacy of non-invasive brain stimulation (NIBS) techniques such as transcranial electrical stimulation (tES) and transcranial magnetic stimulation (TMS) in modulating the activation of crucial nodes of the attentional network. The effect of such neuromudulatory techniques will be studied in neurologically healthy subjects. Visuo-spatial attention will be investigated by means of eye tracking recording, which showed a great potential to study attentional phenomena and allows to test the effects of brain stimulation in more ecological paradigms. My final aim is to gather new pieces of evidence to be applied in the field of assessment and rehabilitation of acquired disorders of attention following brain damage.

Background:

Hemispatial neglect (HN) is a neuropsychological syndrome characterised by a failure or decreased capacity to report, respond or orient to significant stimuli in the contralesional side of space (Heilman & Van Den Abell, 1980). HN occurs more frequently and its symptoms are more persistent after lesions of the right hemisphere (Bowen, McKenna, & Tallis, 1999). Treatment of HN is an issue of great importance, as its presence is an independent predictor of poor functional recovery (Di Monaco et al., 2011). Non-invasive brain stimulation (NIBS) techniques, such as transcranial electrical (tES) and transcranial magnetic (TMS) stimulations, have been proved to be promising approaches for treating HN  (Fan, Li, Yang, Qu, & Li, 2018). However, the interaction of different factors including size and location of the brain lesion, as well as the choice of stimulation parameters (e.g., stimulation intensity and duration, target area etc.) makes further investigation necessary to unravel NIBS full potential in the neuropsychological setting.

Methods:

Both healthy subjects and neglect patients will undergo NIBS sessions where the effect of real vs. sham neurostimulation over parietal cortices, important hubs for visuo-spatial functions, will be tested by means of paper-and-pencil and computerised tasks of visuo-spatial attention such as landmark task, visual search tasks and eye-tracked free visual exploration task. Participants will be tested before the stimulation (Time 0), right after the stimulation (Time 1), and 120 min after the stimulation (Time 2) to assess the duration of the stimulation effects.

PUBLICATIONS

Chapters in book

  • Bolognini, N., & Diana, L. (in press). Multimodal association of tDCS with electroencephalography. In Transcranial Direct Current Stimulation in Neuropsychiatric Disorders (2nd Edition). Springer, Cham.

Articles 

  • Diana, L., Pilastro, P., N. Aiello, E., K. Eberhard-Moscicka, A., M. Müri, R., & Bolognini, N. (2021, May). Saccades, attentional orienting and disengagement: the effects of anodal tDCS over right posterior parietal cortex (PPC) and frontal eye field (FEF). In ACM Symposium on Eye Tracking Research and Applications (pp. 1-7).
  • Diana, L., Frei, M., Chesham, A., de Jong, D., Chiffi, K., Nyffeler, T., … & Müri, R. M. (2020). A divergent approach to pareidolias—Exploring creativity in a novel way. Psychology of aesthetics, creativity, and the arts.
  • Hartmann, M., Sommer, N. R., Diana, L., Müri, R. M., & Eberhard-Moscicka, A. K. (2019). Further to the right: viewing distance modulates attentional asymmetries (‘pseudoneglect’) during visual exploration. Brain and Cognition, 129, 40-48.
  • Paladini, R. E., Diana, L., Zito, G. A., Nyffeler, T., Wyss, P., Mosimann, U. P., … & Cazzoli, D. (2018). Attentional reorienting triggers spatial asymmetries in a search task with cross-modal spatial cueing. PloS one, 13(1), e0190677. 
  • Paladini, R. E., Diana, L., Nyffeler, T., Mosimann, U. P., Nef, T., Müri, R. M., & Cazzoli, D. (2016).       The asymmetrical influence of increasing time-on-task on attentional disengagemet. Neuropsychologia, 92, 107-114.

ALTRE INFORMAZIONI

Elisabetta Donzelli
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