CURRICULUM
Nata a Milano il 29/04/1989. Ho conseguito la laurea triennale in Biotecnologie Farmaceutiche a marzo del 2014 presso l’Università degli Studi di Milano. Durante l’internato di tesi triennale ho acquisito esperienza nella conduzione di test comportamentali e di trattamenti farmacologici sui ratti. Ho conseguito la laurea specialistica in Biotecnologie Mediche nel 2017 presso l’Università degli Studi di Milano – Bicocca (Monza), sviluppando una tesi finalizzata ad indagare il possibile effetto protettivo di sostanze di origine naturale sulla tossicità da beta amiloide e sulla trasduzione del segnale intracellulare in modelli cellulari umani.
Da novembre 2017 frequento il Dottorato di ricerca in Neuroscienze presso l’Università degli Studi di Milano – Bicocca, studiando i possibili effetti benefici di sostanze di origine naturale sulla tossicità indotta da beta amiloide e sulla neuroinfiammazione in modelli umani di cellule periferiche e centrali.
PROGETTO DI RICERCA
Potential role of natural extracts against Aβ cytotoxicity and neuroinflammation
Curriculum: Neuroscienze Sperimentali
Tutor: Carlo Ferrarese
Supervisore: Chiara Paola Zoia
Alzheimer’s disease (AD) is characterized by deposition of amyloid beta peptide (Aβ) plaques and intracellular neurofibrillary tangles, glutamate excitotoxicity and loss of neurons. Aβ-induced oxidative stress plays an important role in AD. Soluble oligomers are the most toxic species of Aβ and they induce cognitive deficit in AD patients. Aβ interacts with several intracellular signals, in particular PI3K/AKT and MAPK, which are also involved in modulation of autophagy, apoptosis and in Aβ and Tau processing. In the last years much attention has been focused on the potential role of using natural compounds, in particular hop and coffee, as neuroprotective agents to attenuate or suppress inflammation, oxidative stress and Aβ-mediated cytotoxicity. Hop contains flavonoids, aromatic molecules which have antioxidant, antinflammatory and antiatherogenic properties. Hop extract has anti-aggregating effects on Aβ and seems to prevent its production in cultured cells. Coffee has antioxidant properties and may have a protective role against cognitive deterioration, too.
In this project will be investigated the potential protective role of coffee and hop against Aβ toxicity in human cellular models. The anti-oxidant/inflammatory properties of hop and coffee extracts and their involvement in kinase signalling, autophagy, apoptosis regulation, APP cleavage and Tau hyperphosphorylation will be assessed. Correlation among inflammation, oxidative stress and glutamate excitotoxicity (glutamate uptake) will be also evaluated.
PUBBLICAZIONI E PARTECIPAZIONI A CONGRESSI RECENTI
Pubblicazioni
- Musazzi, G. Treccani, M. Milanese, C. Perego, N. Nava, P. Tornese, N. Sala, C. Bazzini, A. Malgaroli, J. Nyengaard, G. Wegener, G. Bonanno, M. Popoli. The stress impact on synaptic function and brain architecture: a key to mood and anxiety disorders. (2015) DOI: http://dx.doi.org/10.1016/S0924-977X(15)30105-X
- N. Sala, L. Musazzi, P. Tornese, C. Bazzini, M. Popoli. Chronic treatment with desipramine blocks the time-dependent effects of acute stress on working memory. (2017) DOI: http://dx.doi.org/10.1016/S0924-977X(17)30115-3
- F. La Rosa, M. Saresella, I. Marventano, F. Piancone, E.Ripamonti, N. Al-Daghri, C. Bazzini, C.P. Zoia, E. Conti, C. Ferrarese, M. Clerici. Stavudine Reduces NLRP3 Inflammasome Activation and Modulates Amyloid-β Autophagy. J Alzheimers Dis. 2019 Sep 30. doi: 10.3233/JAD-181259.
- Gironi M, Dalla-Costa G, Frigo M, Rovaris M, Clerici M, Bazzini C, Andreoni S, Comi G, Furlan R, Ferrarese C, Cavaletti G, Saresella M, Zoia CP.
Platelet glutamate uptake and Th1 cells inversely correlate in relapsing/remitting and in progressive multiple sclerosis. Multiple Sclerosis and Related Disorders, Accepted 2020 Feb 10. https://doi.org/10.1016/j.msard.2020.102007
Congressi
- Bazzini C, Sala G, Bolognini A, Airoldi C, Ciaramelli C, Palmioli A, Ferrarese C, Zoia CP “Potential role of Hop and Coffee against amyloid beta toxicity”. 5th NeuroMI International Meeting – Food for Brain: promoting health and preventing diseases. Università di Milano-Bicocca. Milan, 20-22 November 2019
- Bazzini C, La Rosa F, Conti E, Clerici M, Ferrarese C, Saresella M and Zoia CP. “Stavudine inhibits inflammasome down-regulating Ras and GSK/PI3K pathways in amyloid-beta treated THP-1 cells”. XIV Convegno Nazionale SINdem. Florence 7-9 March 2019
- Bazzini C, Conti E, Tremolizzo L, Cereda D, Isella V, Ferrarese C and Zoia CP. “Modulation of MAP-Kinase and PI3K/AKT signaling pathways in fibroblasts from Alzheimer’s Disease patients”. 4th NeuroMI International Meeting – International Conference Brain Stimulation and Brain Plasticity: from Basic Research to Clinical Practice. University of Milano-Bicocca. Milan, 21-23 November 2018
- Zoia CP, Frigo M, Bazzini C, Andreoni S, Fusco ML, Gironi M, Ferrarese C and Cavaletti GA. Modulation of glutamate transport in platelets from Multiple Sclerosis patients. Poster presented at International Symposium Personalised Medicine in Multiple Sclerosis, Università di Milano-Bicocca. Milan, 13-15 September 2017
- Bazzini C, Sala G, Airoldi C, Palmioli A, Bruzzone C, Ferrarerse C, Zoia CP. Signal transduction and β-amyloid cytotoxicity in human fibroblasts: Hop protective role? Poster presented at NeuroMi Annual Meeting 2017
- C.P. Zoia, C. Bazzini, E. Conti, L. Tremolizzo, C. Ferrarese. SiTraNeD: signal transduction on neurodegenerative diseases in peripheral models. Poster presented at International Symposium on Neurobiology Joint Meeting University of Milano Bicocca-University of Surrey January 31, 2017 U6 Building, Martini room Piazza Ateneo Nuovo, 1 Milano – Italy
ALTRE INFO
Per avere altre informazioni, visita:
