Eleonora Pozzi

Eleonora Pozzi

CURRICULUM

Eleonora Pozzi è nata il 7 Agosto 1991. Ha conseguito una laurea triennale in Biotecnologie nel 2013 ed una laurea specialistica in Biologia nel 2016 presso l’Università degli Studi di Milano Bicocca. Dal 2014 prende parte a progetti di ricerca in vivo sulla neurotossicità indotta da farmaci chemioterapici presso l’Unità di Neurologia Sperimentale dell’Università degli Studi di Milano Bicocca, dove attualmente sta frequentando il Dottorato di Ricerca in Neuroscienze.

La sua principale competenza riguarda la creazione ed utilizzo di modelli sperimentali in vivo al fine di studiare le neuropatie periferiche. Ha inoltre esperienza nell’utilizzo delle principali tecniche di biologia molecolare.

PROGETTO DI RICERCA

Oxidative stress in experimental preclinical model Oxaliplatin-Induced Peripheral Neurotoxicity

  • Curriculum: Neuroscienze Sperimentali
  • Tutor: Paola Marmiroli

One of the most neurotoxic antineoplastic drug is oxaliplatin, a platinum-based agent widely used for the treatment of metastatic colorectal cancer. Oxaliplatin is able to induce two clinically distinct forms of peripheral neuropathy: about 90% of patients treated develops an acute and transient syndrome; 20-50% of patients also experience a chronic sensory neuropathy.

Despite the extensive investigation on the symptoms and characteristics of oxaliplatin-induced peripheral neuropathy (OIPN), the pathogenesis is still partially unknown. Mitochondrial dysfunctions and associated oxidative stress may result in a chronic neuronal energy deficit and in neuropathic symptoms.

The aim of this study is to investigate whether mitochondrial impairment may be responsible for the development of neurotoxic effects induced by oxaliplatin. For this purpose, the presence of reactive oxygen species (ROS) in peripheral nervous tissue will be evaluated. Moreover, after verifying the oxidative stress associated to oxaliplatin administration, specific molecules (e.g. mitochondrial protein families) involved in modulation of ROS generation will be investigated.

PUBBLICAZIONI E PARTECIPAZIONI A CONGRESSI RECENTI

Pubblicazioni

Congressi

  • NEUROFILAMENT LIGHT PROTEIN: A BLOOD BIOMARKER OF NEURODEGENERATION IN CHEMOTHERAPY-INDUCED PERIPHERAL NEUROTOXICITY Meregalli C., Fumagalli G., Alberti P., Monza L., Pozzi E., Rodriguez-Menendez V., Sandelius A., Blennow K., Zetterberg H., Marmiroli P., Cavaletti G. XXV Convegno AISAL. Napoli, 4-5 Ottobre 2018.
  • NEW MECHANISMS OF NEUROTOXICITY RELATED TO OXALIPLATIN CHEMOTHERAPY IN MICE Pozzi E., Riva B., Ballarini E., Distasi C., Dionisi M., Ruffinatti F., Renn C., Dorsey S., Genazzani A., Cavaletti G., Marmiroli P., Carozzi V. “2018 PNS Annual Meeting”. Peripheral Nerve Society (PNS), Baltimore, Maryland, 21-25 Luglio 2018.
  • TOPIRAMATE PREVENTS OXALIPLATIN ACUTE EFFECTS ON AXONAL EXCITABILITY Alberti P., Monza L., Fumagalli G., Chiorazzi A., Pozzi E., Meregalli C., Canta A., Cavaletti G. “2018 PNS Annual Meeting”. Peripheral Nerve Society (PNS), Baltimore, Maryland, 21-25 Luglio 2018.
  • THE LINK BETWEEN BENCH AND BED-SIDE: “CLINICAL” NEUROPHYSIOLOGICAL APPROACH TO A RAT MODEL OF NEUROPATHY Alberti P., Fumagalli G., Monza L., Pozzi E., Chiorazzi A., Canta A., Cavaletti G. “2018 PNS Annual Meeting”. Peripheral Nerve Society (PNS), Baltimore, Maryland, 21-25 Luglio 2018.
  • OXALIPLATIN INDUCED PERIPHERAL NEUROTOXICITY: A RAT MODEL THAT REPRODUCES ACUTE AND CHRONIC PHENOMA Alberti P., Monza L., Fumagalli G., Pozzi E., Meregalli C., Carozzi V., Oggioni N,  Marmiroli P., Cavaletti G. VIII Riunione Annuale dell’Associazione Italiana per lo studio del Sistema Nervoso     Periferico (ASNP). Roma, 19-21 Aprile 2018.
  • STANDARD AND ADVANCED NEUROPHYSIOLOGY SET UP IN MOUSE MODELS: SENSORY RECORDINGS AND NERVE EXCITABILITY TESTING OF CAUDAL NERVE Alberti P., Monza L., Fumagalli G., Pozzi E., Meregalli C., Carozzi V., Oggioni N,  Marmiroli P., Cavaletti G. VIII Riunione Annuale dell’Associazione Italiana per lo studio del Sistema Nervoso     Periferico (ASNP). Roma, 19-21 Aprile 2018.
  • STUDY OF PERIPHERAL NEUROTOXICITY OF DIFFERENT DOSES OF OXALIPLATIN IN CD1 MICE Monza L., Fumagalli G., Chiorazzi A., Canta A., Pozzi E., Alberti P., Bossi M., Marmiroli P., Cavaletti G. VIII Riunione Annuale dell’Associazione Italiana per lo studio del Sistema Nervoso     Periferico (ASNP). Roma, 19-21 Aprile 2018.
  • BLOOD NEUROFILAMENT LIGHT CHAINS AS A POTENTIAL DAMAGE MARKER IN CHEMOTHERAPY-INDUCED PERIPHERAL NEUROPATHY RODENT MODELS Fumagalli G., Meregalli C., Monza L., Alberti P., Pozzi E., Carozzi V., Ballarini E., Rodriguez-Menendez V., Oggioni N., Sandelius A., Zetterberg H., Marmiroli P., Cavaletti G. VIII Riunione Annuale dell’Associazione Italiana per lo studio del Sistema Nervoso     Periferico (ASNP). Roma, 19-21 Aprile 2018.
  • ANIMAL MODELS FOR THE STUDY OF HUMAN CENTRAL AND PERIPHERAL NEROVUS SYSTEM DISEASE. Monza L., Fumagalli G., Pozzi E., Alberti P., Canta A., Chiorazzi A., Meregalli C., Carozzi V., Rigolio R., Oggioni N., Marmiroli P., Cavaletti G. XXIV SYMPOSIUM Associazione Italiana per le Scienze degli Animali da Laboratorio (AISAL) 26-27 October 2017, Milan, Italy. Poster
  • INTRAVENOUS IMMUNOGLOBULIN PREPARATION ATTENUATES PAIN BEHAVIORS IN A WISTAR RAT MODEL OF BOTEZOMIB-INDUCED PERIPHERAL NEUROPATHY. Meregalli C., Ballarini E., Monza L., Carozzi V., Chiorazzi A., Canta A., Fumagalli G., Pozzi E., Alberti P., Rodriguez V., Bossi M., Marjanovic I., Scali C., Marmiroli P., Cavaletti G. XXIV SYMPOSIUM Associazione Italiana per le Scienze degli Animali da Laboratorio (AISAL). 26-27 October 2017, Milan, Italy. Poster
  • AN INNOVATIVE TRASLATIONAL APPROACH TO OXALIPLATIN UNDUCED PERIPHERAL NEUROTOXICITY IN ANIMAL MODELS: NERVE EXCITABILITY TESTING. Alberti P., Fumagalli G., Monza L., Pozzi E., Canta A., Chiorazzi A., Oggioni N., Cavaletti G. XXIV SYMPOSIUM Associazione Italiana per le Scienze degli Animali da Laboratorio (AISAL). 26-27 October 2017, Milan, Italy. Poster
  • OXALIPLATIN INDUCED PERIPHERAL NEUROTOXICITY: NERVE EXCITABILITY TESTING FULL PROFILE IN A LONG TERM TOXICITY ANIMAL STUDY. Alberti P., Fumagalli G., Monza L., Pozzi E., Chiorazzi A., Canta A., Cavaletti G. XLVIII Congress of the Italian Neurological Society (SIN). 14-17 October 2017, Naples, Italy. Oral presentation
  • NERVE EXCITABILITY TESTING: AN IN VIVO TRANSLATIONAL APPROACH TO INVESTIGATE OXALIPLATIN INDUCED PERIPHERAL NEUROTOXICITY PATHOGENESIS AND TREATMENT. Alberti P., Fumagalli G., Monza L., Pozzi E., Chiorazzi A., Canta A., Cavaletti G. NeuroMi Annual Meeting 2017. 13-15 September 2017, Milan, Italy. Oral presentation
  • AN IN VIVO AND IN VITRO NEUROPHYSIOLOGICAL APPROACH TO ACUTE AND CHRONIC OXALIPLATIN-INDUCED PERIPHERAL NEUROTOXICITY. Alberti P., Lecchi M., Monza L., Pastori V., Fumagalli G., Pozzi E., Becchetti A., Bostock H., Cavaletti G. 2017 Peripheral Nerve Society (PNS) Annual Meeting. 8-12 July 2017, Sitges, Spain. Poster
  • IVIg EFFECT IN A WISTAR RAT MODEL OF BORTEZOMIB-INDUCED PERIPHERAL NEUROPATHY. Ballarini E., Meregalli C., Carozzi V., Chiorazzi A., Canta A., Monza L., Fumagalli G., Pozzi E., Alberti P., Rodriguez-Menendez V., Bossi M., Marjanovic I., Scali C., Marmiroli P., Cavaletti G. 2017 Peripheral Nerve Society (PNS) Annual Meeting. 8-12 July 2017, Sitges, Spain. Poster
  • ERIBULIN, PACLITAXEL, IXABEPILONE AND VINORELBINE-INDUCED PERIPHERAL NEUROPATHY IN MICE: INSIGHTS IN LONG-TERM RECOVERY. Carozzi VA., Pozzi E., Alberti P., Ballarini E., Rodriguez-Menendez V., Wozniak KM., Wu Y., Liu Y., Littlefield B., Nomoto K., Polydefkis M., Slusher B., Cavaletti G. VII Annual Meeting of the Associazione Italiana per lo studio del Sistema Nervoso Periferico (ASNP). 20-22 April 2017, Bergamo, Italy. Poster
  • EFFECT OF PREVENTIVE AND THERAPEUTIC TREATMENT OF GHRELIN AGONIST HM01 ON THE PERIPHERAL NEUROTOXICITY INDUCED BY BORTEZOMIB IN WISTAR RATS Chiorazzi A., Meregalli C., Oggioni N., Canta A., Carozzi VA., Fumagalli G., Pozzi E., Rodriguez-Menendez V., Marmiroli P., Pietra C., Cavaletti G. VII Annual Meeting of the Associazione Italiana per lo studio del Sistema Nervoso Periferico (ASNP). 20-22 April 2017, Bergamo, Italy. Poster
  • ACCURATE NEUROPHYSIOLOGICAL MONITORING FOR SENSORY NEUROPATHY IN MOUSE MODELS OF CHEMOTHERAPY INDUCED PERIPHERAL NEUROTOXICITY. Alberti P., Fumagalli G., Monza L., Pozzi E., Cavaletti G. VII Annual Meeting of the Associazione Italiana per lo studio del Sistema Nervoso Periferico (ASNP). 20-22 April 2017, Bergamo, Italy. Poster
  • MULTIMODAL EXPERIMENTAL APPROACH TO THE STUDY OF HUMAN NEUROLOGICAL DISEASES. Chiorazzi A., Meregalli C., Canta A., Carozzi VA., Oggioni N., Rigolio R., Pozzi E., Monza L., Fumagalli G., Alberti P., Marmiroli P., Cavaletti G. International Symposium on Neurobiology. 31 Jenuary 2017. Milan, Italy. Poster
  • OXALIPLATIN NEUROTOXICITY IS RELATED TO SLC4A1 EXPRESSION IN BALB/c MICE DORSAL ROOT GANGLIA Ballarini E., Pozzi E., Riva B., Genazzani A., Cavaletti G., Marmiroli P., Carozzi V. XXIII SYMPOSIUM Associazione Italiana per le Scienze degli Animali da Laboratorio (AISAL). 10-11 October 2016, Rome, Italy. Poster
  • EVALUATION OF THE EFFICACY OF PERIPHAGEN NEUROTROPHIN-3 EXPRESSING VECTOR FOR OXALIPLATIN INDUCED PERIPHERAL NEUROPATHY Fumagalli G., Chiorazzi A., Meregalli C., Carozzi VA., Monza L., Pozzi E., Alberti P., Goss J., Krisky D., Wechuck J., Marmiroli P., Cavaletti G. XLVII Congress of the Italian Neurological Society (SIN). 22-25 October 2016, Venice, Italy. Poster
  • THE SEVERITY OF OXALIPALTIN NEUROTOXICITY IS RELATED TO DIFFERENTIAL EXPRESSION OF A SOLUTE TRANSPORTER IN MICE Semperboni S., Carozzi V., Riva B., Pozzi E., Fumagalli G., Cavaletti G., Genazzani A., Marmiroli P. European Meeting of Neuroscience by PhD students II Edition. 29 April 2016, Grenoble, France. Poster
  • THE DIFFERENT SUSCEPTIBILITY TO OXALIPLATIN NEUROTOXICITY IN MICE IS RELATED TO CHANGE IN EXPRESSION OF THE ANION EXCHANGER SLC4A1 Riva B., Marmiroli P., Pozzi E., Lim D., Chiorazzi A., Ballarini E., Genazzani   A.A., Renn C., Dorsey S., Cavaletti G., Carozzi V. VI Annual Meeting of the Associazione Italiana per lo studio del Sistema Nervoso Periferico (ASNP). 14-16 April 2016, Mondello (Palermo), Italy. Poster
  • CAN DIFFERENT MICE STRAINS BE DIFFERENTLY SUSCEPTIBLE TO OXALIPLATIN-INDUCED PERIPHERAL NEUROPATHY? Marmiroli P., Pozzi E., Chiorazzi A., Meregalli C., Oggioni N., Cavaletti G.,  Renn C., Dorsey SG., Carozzi VA. XXII SYMPOSIUM Associazione Italiana per le Scienze degli Animali da Laboratorio (AISAL). 22-24 Ottober 2015, Naples, Italy. Poster
  • OXALIPLATIN-INDUCED PERIPHERAL NEUROTOXICITY: MORPHOLOGICAL CHARACTERIZATION IN DIFFERENT MOUSE STRAINS Carozzi VA., Pozzi E., Chiorazzi A., Meregalli C., Oggioni N., Ballarini E., Canta A., Avezza F., Renn C., Dorsey S., Cavaletti G., Marmiroli P. 69th Meeting of the Italian Society of Anatomy and Histology.17-19 September 2015, Ferrara, Italy. Poster
  • OXALIPLATIN-INDUCED PERIPHERAL NEUROTOXICITY: A ROLE FOR GENOMICS? Marmiroli P., Pozzi E., Riva B., Lim D., Genazzani AA., Cavaletti G., Renn C., Dorsey SG., Carozzi VA. 2015 Peripheral Nerve Society (PNS) Annual Meeting. 27 June – 2 July 2015, Quebec City, Canada. Poster
  • PERIPHERAL NEUROTOXICITY INDUCED BY CISPLATIN: A POSSIBLE ROLE OF OCT2 GENE Chiorazzi A., Ceresa C., Canta A., Pozzi E., Cavaletti G., Marmiroli P. V Annual Meeting of the Associazione Italiana per lo studio del Sistema Nervoso Periferico (ASNP). 9-11 April 2015, Turin, Italy. Poster

ALTRE INFO

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